University of Arizona, College of Medicine-Phoenix, AZ 85004, USA.
University of Arizona, Sarver Heart Center, Tucson, AZ 85724, USA.
Future Cardiol. 2024;20(11-12):619-625. doi: 10.1080/14796678.2024.2387939. Epub 2024 Aug 13.
Depression has been suggested to increase the risk of cardiovascular disease, but many studies assessed depression after heart disease onset. This study evaluated the association between depression and myocardial infarction (MI) using a large inpatient database. We analyzed patients from the National Inpatient Sample hospitals from 2005 to 2020, selecting those aged >30 with ICD-9 and ICD-10 codes for segment elevation (ST) elevation myocardial infarction (STEMI), non-ST elevation myocardial elevation (NSTEMI) and major depression. Our data included 4413,113 STEMI patients (224,430 with depression) and 10,421,346 NSTEMI patients (437,058 with depression). No significant association was found between depression and MI. For STEMI, the 2005 odds ratio was 0.12 (95% CI: 0.10-0.15, < 0.001) and the 2020 odds ratio was 0.71 (95% CI: 0.69-0.73, < 0.001). Similar patterns were observed for NSTEMI. Depression may not independently be a significant risk factor for MI.
抑郁症被认为会增加心血管疾病的风险，但许多研究都是在心脏病发作后评估抑郁症。本研究使用大型住院患者数据库评估了抑郁症与心肌梗死（MI）之间的关系。我们分析了 2005 年至 2020 年国家住院患者样本医院的患者，选择了年龄大于 30 岁、具有 ICD-9 和 ICD-10 编码的患者，这些编码用于诊断 ST 段抬高型心肌梗死（STEMI）、非 ST 段抬高型心肌梗死（NSTEMI）和重度抑郁症。我们的数据包括 4413113 例 STEMI 患者（224430 例患有抑郁症）和 10421346 例 NSTEMI 患者（437058 例患有抑郁症）。我们未发现抑郁症与 MI 之间存在显著关联。对于 STEMI，2005 年的比值比为 0.12（95%可信区间：0.10-0.15，<0.001），2020 年的比值比为 0.71（95%可信区间：0.69-0.73，<0.001）。NSTEMI 也观察到了类似的模式。抑郁症可能不是 MI 的独立危险因素。
