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[Giant cell arteritis after the age of 75].

作者信息

Chevalet Pascal, Masseau-Imbert Agathe, Durand-Fix Marie-Hélène, Agard Christian, Brisseau Jean-Marie, Rodat Olivier, Barrier Jacques-Henri

机构信息

Service de Médecine Polyvalente Gériatrique, Hôpital Bellier, 41, rue Curie, BP 84607, 44046 Nantes Cedex 1, France.

出版信息

Ann Med Interne (Paris). 2002 Oct;153(6):373-7.

Abstract

Despite its increasing incidence giant cell arteritis is not well detected in the elderly. Response to corticosteroid treatment is the same before and after the age of 75, but there are many steroid-induced side effects, particularly bone fractures, in the elderly. Therefore, it is important to reduce the corticosteroid load in elderly and frail people. In this cases, 0.3 to 0.5mg/kg, or 15 to 25mg daily prednisone-equivalent dose at start seems to be enough to prevent blindness in simple forms. This dose has to be rapidly reduced whenever the C-reactive protein remains moderately elevated. Moreover, an anti-agregant or anticoagulant treatment must be associated at the beginning of steroid treatment to prevent ischemic complications, as well as biphosphonates, which could prevent corticosteroid-induced osteoporosis.

摘要

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