Chial Heather J, Camilleri Michael, Burton Duane, Thomforde George, Olden Kevin W, Stephens Debra
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G130-7. doi: 10.1152/ajpgi.00266.2002.
This study evaluated the effects of serotonergic psychoactive agents on gastrointestinal functions in healthy human subjects. Participants received one of four regimens in a randomized, double-blind manner: buspirone, a 5-HT(1A) receptor agonist (10 mg twice daily); paroxetine, a selective serotonin reuptake inhibitor (20 mg daily); venlafaxine-XR, a selective serotonin and norepinephrine reuptake inhibitor (75 mg daily); or placebo for 11 days. Physiological testing performed on days 8-11 included scintigraphic assessment of gastrointestinal and colonic transit, the nutrient drink test, and assessment of the postprandial change in gastric volume. Fifty-one healthy adults (40 females, 11 males) participated in this study. No effects on gastric emptying or colonic transit were identified with any agent. Small bowel transit of a solid meal was accelerated by paroxetine. Buspirone decreased postprandial aggregate symptom and nausea scores. Venlafaxine-XR increased the postprandial change in gastric volume. Buspirone, paroxetine, and venlafaxine-XR affect upper gastrointestinal functions in healthy humans. These data support the need for clinical and physiological studies of these agents in functional gastrointestinal disorders.
本研究评估了血清素能精神活性药物对健康人体胃肠道功能的影响。参与者以随机、双盲的方式接受以下四种治疗方案之一：丁螺环酮，一种5-HT(1A)受体激动剂（每日两次，每次10毫克）；帕罗西汀，一种选择性5-羟色胺再摄取抑制剂（每日20毫克）；文拉法辛缓释剂，一种选择性5-羟色胺和去甲肾上腺素再摄取抑制剂（每日75毫克）；或安慰剂，为期11天。在第8 - 11天进行的生理测试包括胃肠道和结肠转运的闪烁扫描评估、营养饮料测试以及餐后胃容积变化的评估。51名健康成年人（40名女性，11名男性）参与了本研究。未发现任何药物对胃排空或结肠转运有影响。帕罗西汀加速了固体食物的小肠转运。丁螺环酮降低了餐后总体症状和恶心评分。文拉法辛缓释剂增加了餐后胃容积的变化。丁螺环酮、帕罗西汀和文拉法辛缓释剂影响健康人的上胃肠道功能。这些数据支持对这些药物在功能性胃肠疾病中进行临床和生理研究的必要性。
