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脂肪酸对金黄色葡萄球菌δ-毒素溶血活性的影响。

Effect of fatty acids on Staphylococcus aureus delta-toxin hemolytic activity.

作者信息

Kapral F A

出版信息

Infect Immun. 1976 Jan;13(1):114-9. doi: 10.1128/iai.13.1.114-119.1976.

DOI:10.1128/iai.13.1.114-119.1976
PMID:1248865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC420584/
Abstract

The lysis of human erythrocytes by Staphylococcus aureus delta-toxin proceeded without a lag and was directly proportional to toxin concentration and temperature of incubation. Lysis was complete within 8 min. Addition of saturated, straight-chain fatty acids of 13 to 19 carbons increased the activity of delta-toxin, whereas those with 21 to 23 carbons were inhibitory. Palmitic acid was the fatty acid most active in augmenting delta-toxin, but its effect could be abolished by the simultaneous addition of either tricosanoic acid or egg lecithin.

摘要

金黄色葡萄球菌δ-毒素对人红细胞的裂解过程没有延迟，且与毒素浓度和孵育温度成正比。8分钟内裂解完成。添加13至19个碳的饱和直链脂肪酸可增强δ-毒素的活性，而21至23个碳的脂肪酸则具有抑制作用。棕榈酸是增强δ-毒素活性最有效的脂肪酸，但其作用可被同时添加的二十三烷酸或卵磷脂消除。

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本文引用的文献

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Staphylococcal delta-haemolysin.葡萄球菌δ-溶血素
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Staphylococcal toxins. II. Factors affecting hemolysis by delta-lysin.葡萄球菌毒素。II. 影响δ-溶血素溶血作用的因素。
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Product of Staphylococcus aureus responsible for the scalded-skin syndrome.金黄色葡萄球菌产生的导致烫伤样皮肤综合征的产物。
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Characterization and partial purification of staphylococcal delta-lysin.葡萄球菌δ-溶血素的特性鉴定与部分纯化
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Proc Soc Exp Biol Med. 1972 Nov;141(2):519-21. doi: 10.3181/00379727-141-36812.
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Staphylococcal delta hemolysin: purification and characterization.葡萄球菌δ溶血素：纯化与特性分析
Arch Biochem Biophys. 1972 Jul;151(1):142-56. doi: 10.1016/0003-9861(72)90483-3.
9
Phospholipase activity of the delta hemolysin of Staphylococcus aureus.金黄色葡萄球菌δ溶血素的磷脂酶活性
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Comparative effects of purified staphylococcal alpha and delta toxins on mitochondrial metabolism.纯化的葡萄球菌α毒素和δ毒素对线粒体代谢的比较作用
J Infect Dis. 1972 Jul;126(1):96-103. doi: 10.1093/infdis/126.1.96.