一氧化氮可抑制溶组织内阿米巴的半胱氨酸蛋白酶和乙醇脱氢酶2。
Nitric oxide inhibits cysteine proteinases and alcohol dehydrogenase 2 of Entamoeba histolytica.
作者信息
Siman-Tov Rama, Ankri Serge
机构信息
Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O.Box 9649, 31096 Haifa, Israel.
出版信息
Parasitol Res. 2003 Jan;89(2):146-9. doi: 10.1007/s00436-002-0716-2. Epub 2002 Aug 15.
Nitric oxide is involved in the neutrophil and macrophage killing of the protozoan parasite Entamoeba histolytica. In the present study, we found that cysteine proteinases, significant contributors to amebic virulence and alcohol dehydrogenase 2, an enzyme absolutely required for the survival of the parasite, are both significantly inhibited by S-nitroso-glutathione, a physiological nitric oxide donor, within the concentration range 0.5-2.0 m M.
一氧化氮参与中性粒细胞和巨噬细胞对原生动物寄生虫溶组织内阿米巴的杀伤作用。在本研究中，我们发现半胱氨酸蛋白酶（阿米巴毒力的重要贡献者）和乙醇脱氢酶2（该寄生虫生存绝对必需的一种酶）在浓度范围为0.5 - 2.0 mM的生理一氧化氮供体S-亚硝基谷胱甘肽作用下均受到显著抑制。
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