用于硫醇依赖性转亚硝化作用及对成年雌性丝虫毒性的S-亚硝基化聚硫化丙烯纳米颗粒
S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.
作者信息
Schudel Alex, Kassis Timothy, Dixon J Brandon, Thomas Susan N
机构信息
School of Materials Science and Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.
出版信息
Adv Healthc Mater. 2015 Jul 15;4(10):1484-90, 1423. doi: 10.1002/adhm.201400841. Epub 2015 May 4.
Abstract
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor.
摘要
展示了一种利用生理亚硝基硫醇化学用于一氧化氮递送的合成聚合物纳米颗粒制剂。S-亚硝基纳米颗粒对导致淋巴丝虫病的成年雌性马来布鲁线虫的毒性取决于通过转亚硝化作用释放的一氧化氮，转亚硝化作用是以S-亚硝基半胱氨酸这种有效的内源性一氧化氮供体形式进行的。
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