Basser Peter J, Jones Derek K
Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
NMR Biomed. 2002 Nov-Dec;15(7-8):456-67. doi: 10.1002/nbm.783.
This article treats the theoretical underpinnings of diffusion-tensor magnetic resonance imaging (DT-MRI), as well as experimental design and data analysis issues. We review the mathematical model underlying DT-MRI, discuss the quantitative parameters that are derived from the measured effective diffusion tensor, and describe artifacts that arise in typical DT-MRI acquisitions. We also discuss difficulties in identifying appropriate models to describe water diffusion in heterogeneous tissues, as well as in interpreting experimental data obtained in such issues. Finally, we describe new statistical methods that have been developed to analyse DT-MRI data, and their potential uses in clinical and multi-site studies.
本文探讨了扩散张量磁共振成像（DT-MRI）的理论基础，以及实验设计和数据分析问题。我们回顾了DT-MRI的数学模型，讨论了从测量的有效扩散张量导出的定量参数，并描述了典型DT-MRI采集中出现的伪影。我们还讨论了在识别用于描述异质组织中水扩散的合适模型以及解释在此类问题中获得的实验数据方面的困难。最后，我们描述了为分析DT-MRI数据而开发的新统计方法，以及它们在临床和多中心研究中的潜在用途。
