Neil J, Miller J, Mukherjee P, Hüppi P S
Department of Radiology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA.
NMR Biomed. 2002 Nov-Dec;15(7-8):543-52. doi: 10.1002/nbm.784.
The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusion coefficient and diffusion anisotropy measures-change dramatically during development, reflecting underlying changes in tissue water content and cytoarchitecture. DTI parameters also change in response to brain injury. In this context, not only does DTI offer the possibility of detecting injury earlier than conventional imaging methods, but also appears more sensitive to disruption of white matter than any other imaging method. DTI offers unique insight into brain injury and maturation, and does so in a fashion that can be readily applied in a clinical setting.
将扩散张量成像（DTI）应用于发育中大脑的评估仍是一个活跃的研究领域。本综述聚焦于伴随大脑成熟和损伤的DTI参数变化。DTI研究可获得的两个主要信息——水的表观扩散系数和扩散各向异性测量值——在发育过程中会发生显著变化，反映了组织含水量和细胞结构的潜在变化。DTI参数也会因脑损伤而改变。在这种情况下，DTI不仅有可能比传统成像方法更早地检测到损伤，而且对白质破坏的敏感性似乎比任何其他成像方法都更高。DTI为脑损伤和成熟提供了独特的见解，并且是以一种可轻易应用于临床环境的方式做到这一点的。
