Verreijdt L, Vandervennet E, Sire J Y, Huysseune A
Ghent University, Department of Biology, K. L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
Connect Tissue Res. 2002;43(2-3):109-12. doi: 10.1080/03008200290001087.
To test whether cartilage bones and dermal bones, which belong to two different units of the vertebrate skeleton, have distinct developmental programs possibly reflected in a different molecular control of their ossification process, we currently investigate the development of some selected cranial bones in the zebrafish, Danio rerio. Here we present some light microscopical and ultrastructural findings with respect to the maxillary bone (a dermal bone that is edentulous in the zebrafish) and the basioccipital bone (a cartilage bone, i.e., with a perichondral phase followed by endochondral invasion). The two bones differ in (a) the area where matrix is first deposited--an unstructured extracellular domain in the former versus intermingling of bone matrix elements with cartilage matrix in the latter--and (b) the progression of ossification--continuously from an initium in the former versus through fusion of separate anlagen in the latter. These findings seem to support the hypothesis that the two types of bone have at least some distinctive features in their developmental programs.
为了检验属于脊椎动物骨骼两个不同单元的软骨性骨和膜性骨是否具有截然不同的发育程序，这可能体现在它们骨化过程的不同分子调控上，我们目前正在研究斑马鱼（Danio rerio）中一些选定颅骨的发育情况。在此，我们展示了关于上颌骨（斑马鱼中无牙的膜性骨）和基枕骨（软骨性骨，即先有软骨膜阶段，随后有软骨内侵入）的一些光学显微镜和超微结构研究结果。这两块骨头在以下方面存在差异：（a）首先沉积基质的区域——前者是一个无结构的细胞外区域，而后者是骨基质成分与软骨基质相互交织；（b）骨化进程——前者从起始点持续进行，而后者是通过单独原基的融合进行。这些发现似乎支持了这样一种假说，即这两种类型的骨在其发育程序中至少具有一些独特的特征。
