吡喃霉素，一类具有改善酸稳定性的新型氨基糖苷类抗生素：吡喃霉素III环上D-吡喃糖的构效关系。

Pyranmycins, a novel class of aminoglycosides with improved acid stability: the SAR of D-pyranoses on ring III of pyranmycin.

作者信息

Chang Cheng-Wei Tom, Hui Yu, Elchert Bryan, Wang Jinhua, Li Jie, Rai Ravi

机构信息

Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA.

出版信息

Org Lett. 2002 Dec 26;4(26):4603-6. doi: 10.1021/ol0269042.

DOI:10.1021/ol0269042

PMID:12489940

Abstract

[reaction: see text] The synthesis of a novel class of aminoglycosides, pyranmycins, is reported along with the structure activity relationship (SAR) of their antibacterial activity against Escherichia coli. Two pyranmycins show prominent activity (9 microM). Pyranmycins also manifest superior stability in acidic media. The SAR information will lead to the future designs of pyranmycin against drug resistant bacteria.

摘要

[反应：见正文] 报道了一类新型氨基糖苷类化合物——吡喃霉素的合成及其对大肠杆菌抗菌活性的构效关系（SAR）。两种吡喃霉素显示出显著活性（9微摩尔）。吡喃霉素在酸性介质中也表现出优异的稳定性。构效关系信息将为未来针对耐药菌的吡喃霉素设计提供指导。