Kim Joseph T, Gevorgyan Vladimir
Department of Chemistry, University of Illinois at Chicago, 875 West Taylor Street, Chicago, Illinois 60607-7061, USA.
Org Lett. 2002 Dec 26;4(26):4697-9. doi: 10.1021/ol027129t.
[reaction: see text] Cu-Assisted double cycloisomerization of bis-alkynylpyrimidines afforded the 5-6-5 tricyclic heteroaromatic skeleton. This transformation was used as a key step in the highly diastereoselective total synthesis of (+/-)-tetraponerine T6.
[反应:见正文] 双炔基嘧啶的铜辅助双环异构化反应生成了5-6-5三环杂芳骨架。该转化反应被用作(±)-四ponerine T6的高非对映选择性全合成中的关键步骤。