泰德内酯的合成研究。2. 一个受保护的C(1)-C(12)片段的立体选择性合成。

Studies on the synthesis of tedanolide. 2. Stereoselective synthesis of a protected C(1)-C(12) fragment.

作者信息

Roush William R, Newcom Jason S

机构信息

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

出版信息

Org Lett. 2002 Dec 26;4(26):4739-42. doi: 10.1021/ol0272343.

DOI:10.1021/ol0272343

PMID:12489975

Abstract

[reaction: see text] Highly diastereoselective syntheses of diketo esters 6a and 6b are described. These intermediates undergo efficient aldol reactions with protected C(13)-C(21) aldehydes 3 and 23, thereby providing advanced C(1)-C(21) tedanolide seco ester precursors 9a and 9b.

摘要

[反应：见正文] 描述了二酮酯6a和6b的高度非对映选择性合成。这些中间体与受保护的C(13)-C(21)醛3和23进行有效的羟醛反应，从而提供高级的C(1)-C(21)替达诺内酯开环酯前体9a和9b。