Toward the synthesis of reidispongiolide a: stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.
作者信息
Paterson Ian, Ashton Kate, Britton Robert, Knust Henner
机构信息
Department of Chemistry, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
出版信息
Org Lett. 2003 May 29;5(11):1963-6. doi: 10.1021/ol034558y.
PMID:12762697
Abstract
[structure: see text] By relying on the asymmetric aldol reactions of chiral ketones, a highly stereocontrolled synthesis of each of the C(17)-C(22) and C(23)-C(35) degradation fragments of reidispongiolide A has been achieved. This permits a configurational assignment of the complete C(17)-C(36) region of this antimitotic macrolide, along with providing advanced intermediates for a projected total synthesis.
摘要
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