Harris-Warrick Ronald M
Department of Neurobiology and Behavior, Seeley G. Mudd Hall, Cornell University, Ithaca, New York 14853, USA.
Curr Opin Neurobiol. 2002 Dec;12(6):646-51. doi: 10.1016/s0959-4388(02)00377-x.
Voltage-sensitive ionic currents shape both the firing properties of neurons and their synaptic integration within neural networks that drive rhythmic motor patterns. Persistent sodium currents underlie rhythmic bursting in respiratory neurons. H-type pacemaker currents can act as leak conductances in spinal motoneurons, and also control long-term modulation of synaptic release at the crayfish neuromuscular junction. Calcium currents travel in rostro-caudal waves with motoneuron activity in the spinal cord. Potassium currents control spike width and burst duration in many rhythmic motor systems. We are beginning to identify the genes that underlie these currents.
电压敏感性离子电流塑造了神经元的放电特性及其在驱动节律性运动模式的神经网络中的突触整合。持续性钠电流是呼吸神经元节律性爆发的基础。H型起搏电流可作为脊髓运动神经元的漏电导，还可控制小龙虾神经肌肉接头处突触释放的长期调节。钙电流随着脊髓中运动神经元的活动以头-尾波的形式传播。钾电流在许多节律性运动系统中控制动作电位宽度和爆发持续时间。我们开始鉴定这些电流所依赖的基因。
