Duncan Stephen A
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Mech Dev. 2003 Jan;120(1):19-33. doi: 10.1016/s0925-4773(02)00328-3.
Over the last decade significant advances have been made in our understanding of the molecular mechanisms that control early aspects of mammalian liver development. Studies using tissue explant cultures and molecular biology techniques as well as the analysis of transgenic and knockout mice have identified signaling molecules and transcription factors that are necessary for the onset of hepatogenesis. This review presents an overview of these studies and discusses the role of individual factors during hepatic development.
在过去十年中，我们对控制哺乳动物肝脏早期发育分子机制的理解取得了重大进展。利用组织外植体培养和分子生物学技术以及对转基因和基因敲除小鼠的分析进行的研究，已经确定了肝发生起始所必需的信号分子和转录因子。本综述概述了这些研究，并讨论了各个因子在肝脏发育过程中的作用。
