内皮细胞在胰腺和肝脏早期发育中的作用。

Role of endothelial cells in early pancreas and liver development.

作者信息

Lammert Eckhard, Cleaver Ondine, Melton Douglas

机构信息

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

出版信息

Mech Dev. 2003 Jan;120(1):59-64. doi: 10.1016/s0925-4773(02)00332-5.

DOI:10.1016/s0925-4773(02)00332-5

PMID:12490296

Abstract

Liver and pancreas initially develop by budding from the embryonic endoderm. The formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent to the endoderm. ECs either develop in situ in organs, or are recruited by organs and are induced to form blood vessels. Recent reports on liver and pancreas have now shown that ECs also induce essential steps in organ formation such as morphogenesis and cell differentiation. This review summarizes reports on EC signaling during organogenesis and cell differentiation.

摘要

肝脏和胰腺最初是由胚胎内胚层出芽发育而来。这些器官的形成与内胚层附近内皮细胞（ECs）的出现同时发生。内皮细胞要么在器官原位发育，要么被器官招募并被诱导形成血管。最近关于肝脏和胰腺的报道表明，内皮细胞还能诱导器官形成过程中的关键步骤，如形态发生和细胞分化。本综述总结了器官发生和细胞分化过程中内皮细胞信号传导的相关报道。