Bishop Daniel, Schwarz Quenten, Wiszniak Sophie
Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
Front Cell Dev Biol. 2023 Jun 29;11:1172114. doi: 10.3389/fcell.2023.1172114. eCollection 2023.
Blood vessels are well-known to play roles in organ development and repair, primarily owing to their fundamental function in delivering oxygen and nutrients to tissues to promote their growth and homeostasis. Endothelial cells however are not merely passive conduits for carrying blood. There is now evidence that endothelial cells of the vasculature actively regulate tissue-specific development, morphogenesis and organ function, as well as playing roles in disease and cancer. Angiocrine factors are growth factors, cytokines, signaling molecules or other regulators produced directly from endothelial cells to instruct a diverse range of signaling outcomes in the cellular microenvironment, and are critical mediators of the vascular control of organ function. The roles of angiocrine signaling are only beginning to be uncovered in diverse fields such as homeostasis, regeneration, organogenesis, stem-cell maintenance, cell differentiation and tumour growth. While in some cases the specific angiocrine factor involved in these processes has been identified, in many cases the molecular identity of the angiocrine factor(s) remain to be discovered, even though the importance of angiocrine signaling has been implicated. In this review, we will specifically focus on roles for endothelial-derived angiocrine signaling in instructing tissue morphogenesis and organogenesis during embryonic and perinatal development.
众所周知，血管在器官发育和修复中发挥作用，这主要归因于其在为组织输送氧气和营养物质以促进其生长和内环境稳定方面的基本功能。然而，内皮细胞不仅仅是输送血液的被动管道。现在有证据表明，脉管系统的内皮细胞积极调节组织特异性发育、形态发生和器官功能，以及在疾病和癌症中发挥作用。血管分泌因子是直接由内皮细胞产生的生长因子、细胞因子、信号分子或其他调节剂，用于在细胞微环境中指导多种信号转导结果，并且是器官功能血管控制的关键介质。血管分泌信号传导的作用在诸如内环境稳定、再生、器官发生、干细胞维持、细胞分化和肿瘤生长等不同领域才刚刚开始被揭示。虽然在某些情况下已经确定了参与这些过程的特定血管分泌因子，但在许多情况下，即使血管分泌信号传导的重要性已被暗示，血管分泌因子的分子身份仍有待发现。在这篇综述中，我们将特别关注内皮衍生的血管分泌信号传导在胚胎和围产期发育过程中指导组织形态发生和器官发生方面的作用。
