Punyadeera Chamindie, Crowther Nigel J, van der Merwe Maria-Terésa, Toman Marketa, Immelman Andrew Ronnie, Schlaphoff Glen P, Gray Ian Peter
Department of Chemical Pathology, National Health Laboratory Service, University of the Witwatersrand Faculty of Health Sciences, Johannesburg, South Africa.
Obes Res. 2002 Dec;10(12):1207-16. doi: 10.1038/oby.2002.165.
Lower lipid and insulin levels are found during a glucose-tolerance test in obese black than obese white South African women. Therefore, beta-cell function and lipid metabolism were compared in these populations during a mixed meal.
Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose-casein-sucrose-lipid and [1-(13)C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.
Visceral fat area was higher in OWW (152.7 +/- 17.0 cm(2)) than OBW (80.0 +/- 6.7 cm(2); p < 0.01). In OBW, 30-minute insulin levels were higher (604.3 +/- 117.6 pM) than OWW (311.0 +/- 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 +/- 96.0 mM x 7 hours) than OBW (465.7 +/- 48.2 mM x 7 hours; p < 0.05) and correlated with visceral fat area (beta = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (beta = -0.58, p < 0.005).
The higher 30-minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.
在葡萄糖耐量试验中，发现南非肥胖黑人女性的血脂和胰岛素水平低于肥胖白人女性。因此，在混合餐期间对这些人群的β细胞功能和脂质代谢进行了比较。
在8名瘦黑人女性（LBW）、10名肥胖黑人女性（OBW）、9名瘦白人女性（LWW）和10名肥胖白人女性（OWW）中，测定了空腹以及口服含葡萄糖 - 酪蛋白 - 蔗糖 - 脂质和[1 - （13）C]棕榈酸的混合乳剂后7小时的血糖、游离脂肪酸（FFA）、胰岛素、血脂谱和体内FFA氧化水平。通过计算机断层扫描评估皮下和内脏脂肪量。
肥胖白人女性（OWW）的内脏脂肪面积（152.7±17.0平方厘米）高于肥胖黑人女性（OBW）（80.0±6.7平方厘米；p<0.01）。在肥胖黑人女性中，30分钟时的胰岛素水平（604.3±117.6皮摩尔）高于肥胖白人女性（311.0±42.9皮摩尔；p<0.05）。肥胖白人女性的总甘油三酯水平（706.7±96.0毫摩尔×7小时）高于肥胖黑人女性（465.7±48.2毫摩尔×7小时；p<0.05），且与内脏脂肪面积相关（β = 0.38，p = 0.05）。在两个种族群体中，瘦女性的棕榈酸氧化均高于肥胖女性，且与脂肪量呈负相关（β = -0.58，p<0.005）。
肥胖黑人女性30分钟时较高的胰岛素反应可能反映了游离脂肪酸或葡萄糖更高的促胰岛素分泌作用。肥胖白人女性甘油三酯水平升高可能是由于其较高的内脏脂肪量以及脂肪组织清除能力可能降低。
