Bilbao Daniel, Valcárcel Juan
Nat Struct Biol. 2003 Jan;10(1):6-7. doi: 10.1038/nsb0103-6.
Dinucleotide CA repeats of variable length in an intron of the human endothelial nitric oxide synthase gene act as regulatory signals for splicing of the gene's pre-mRNA. Repeat length-dependent binding of hnRNP L to the repeats provides an intriguing link between splicing efficiency, nitric oxide synthesis and cardiovascular disease.
人类内皮型一氧化氮合酶基因一个内含子中可变长度的二核苷酸CA重复序列充当该基因前体mRNA剪接的调控信号。异质性核糖核蛋白L与这些重复序列的重复长度依赖性结合在剪接效率、一氧化氮合成和心血管疾病之间建立了一个有趣的联系。
