Gulhas N, Turkoz A, Durmus M, Togal T, Gedik E, Ersoy M O
Department of Anesthesia, Inonu University Turgut Ozal Medical Center, Turkey.
Acta Anaesthesiol Scand. 2003 Jan;47(1):90-3. doi: 10.1034/j.1399-6576.2003.470116.x.
We evaluated the effect of oral clonidine on postoperative vomiting (POV) in children undergoing strabismus surgery.
Eighty ASA physical status I children aged 3-12 years were randomly assigned to one of two groups in a double-blinded manner. One hour before surgery, each patient in the clonidine group (n=40) received clonidine 4 micro g kg-1 in apple juice 0.2 ml kg-1, and each of the controls (n=40) received apple juice 0.2 ml kg-1 only. The protocol for general anesthesia was propofol-sevoflurane in N2O/O2. A paracetamol suppository was administered in each case to prevent postoperative pain. Patient responses during 0-48 h after anesthesia were recorded as complete (no POV, no antiemetic rescue required), retching, vomiting, or rescue antiemetic.
There were no significant differences between the clonidine and control groups regarding the number of patients with complete response (21 vs. 18, respectively) retching (10 vs. 14, respectively), vomiting (19 vs. 22, respectively), or rescue antiemetic (9 vs. 12, respectively) during the first 48 h.
Oral premedication with clonidine 4 micro g kg-1 did not reduce the rate of POV in the children undergoing strabismus surgery.
我们评估了口服可乐定对斜视手术患儿术后呕吐（POV）的影响。
80名年龄在3至12岁、ASA身体状况为I级的儿童以双盲方式随机分为两组。手术前1小时，可乐定组（n = 40）的每名患者接受溶入0.2 ml/kg苹果汁中的4μg/kg可乐定，而对照组（n = 40）的每名患者仅接受0.2 ml/kg苹果汁。全身麻醉方案为丙泊酚-七氟醚复合笑气/氧气。每例均给予对乙酰氨基酚栓剂以预防术后疼痛。记录麻醉后0至48小时内患者的反应，分为完全缓解（无POV，无需使用止吐药解救）、干呕、呕吐或使用解救性止吐药。
在最初的48小时内，可乐定组和对照组在完全缓解患者数量（分别为21例和18例）、干呕（分别为10例和14例）、呕吐（分别为19例和22例）或使用解救性止吐药（分别为9例和12例）方面无显著差异。
术前口服4μg/kg可乐定不能降低斜视手术患儿的POV发生率。
