Loftis Jennifer M, Janowsky Aaron
Research Service, Department of Veterans Affairs Medical Center, Mental Health (P3MHDC), 3710 SW U.S. Veterans Hospital Road, Portland, OR 97201, USA.
Pharmacol Ther. 2003 Jan;97(1):55-85. doi: 10.1016/s0163-7258(02)00302-9.
The N-methyl-D-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins by way of different subunits. NMDA receptors are composed of seven known subunits (NR1, NR2A-D, NR3A-B). The present review focuses on the NR2B subunit of the receptor. Over the last several years, an increasing number of reports have demonstrated the importance of the NR2B subunit in a variety of synaptic signaling events and protein-protein interactions. The NR2B subunit has been implicated in modulating functions such as learning, memory processing, pain perception, and feeding behaviors, as well as being involved in a number of human disorders. The following review provides a summary of recent findings regarding the structural features, localization, functional properties, and regulation of the NR2B subunit. The review concludes with a section discussing the role of NR2B in human diseases.
N-甲基-D-天冬氨酸（NMDA）受体是一种异源配体门控离子通道，它通过不同的亚基与多种细胞内蛋白质相互作用。NMDA受体由七个已知亚基（NR1、NR2A-D、NR3A-B）组成。本综述聚焦于该受体的NR2B亚基。在过去几年中，越来越多的报告表明NR2B亚基在各种突触信号事件和蛋白质-蛋白质相互作用中具有重要性。NR2B亚基已被认为与调节学习、记忆处理、痛觉感知和进食行为等功能有关，并且还涉及多种人类疾病。以下综述总结了关于NR2B亚基的结构特征、定位、功能特性及调节的最新研究结果。综述最后一部分讨论了NR2B在人类疾病中的作用。
