Schmucker D L
J Gerontol. 1976 Mar;31(2):135-43. doi: 10.1093/geronj/31.2.135.
Age-related changes in hepatic fine structure were quantitatively evaluated in virgin and retired breeder (RB) male rats by morphometric analysis. Centrolobular hepatocytes increase in size, at least up to 480 days of age, and this increase is reflected in larger volumes of nuclei, cytoplasm, organelles, and ground substance. The surface area of the smooth-surfaced endoplasmic reticulum (SER) continues to increase with age in both groups of animals, although there is a significantly greater amount of both SER and rough-surfaced endoplasmic reticulum in the livers of the virgin rats. In addition, aging is accompanied by a gradual increase in the relative volume of the lysosomes and a linear decrease in the surface area of the Golgi membranes. Evidence from this study suggests that specific alterations in hepatic fine structure occur as a function of age.
通过形态计量分析，对未交配和繁殖后期（RB）雄性大鼠肝脏的细微结构随年龄的变化进行了定量评估。小叶中央肝细胞的大小会增加，至少在480日龄之前如此，这种增加反映在细胞核、细胞质、细胞器和基质的体积增大上。在两组动物中，光滑内质网（SER）的表面积均随年龄增长而持续增加，不过未交配大鼠肝脏中的SER和粗面内质网的量均显著更多。此外，衰老伴随着溶酶体相对体积的逐渐增加以及高尔基体膜表面积的线性减少。这项研究的证据表明，肝脏细微结构的特定改变是年龄的函数。
