Preobrazhenskiĭ D V, Marenitch A V, Shatunova I M, Sidorenko B A
Kardiologiia. 2002;42(6):79-85.
Analysis of controlled randomized studies of efficacy of antihypertensive drugs in primary and secondary prevention of stroke is presented. Basing on this analysis a conclusion is made that in patients with hypertension representatives of all 4 main classes of antihypertensive drugs prevent stroke with similar efficacy. Magnitude of reduction of risk of both first and recurrent stroke is determined not by the class of a drug but by degree of blood pressure lowering. Special emphasis is made on necessity of careful approach to blood pressure lowering in elderly patients.
本文对降压药物在脑卒中一级和二级预防中疗效的对照随机研究进行了分析。基于该分析得出结论：在高血压患者中，所有4种主要降压药物类别均可有效预防脑卒中，且疗效相似。首次卒中和复发性卒中风险降低的程度并非取决于药物类别，而是取决于血压降低的程度。文中特别强调了老年患者降压治疗时谨慎用药的必要性。
