喹诺酮生物碱，吴茱萸果实中的二酰基甘油酰基转移酶抑制剂。

Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa.

作者信息

Ko Jeong Suk, Rho Mun-Chual, Chung Mi Yeon, Song Hye Young, Kang Jong Seong, Kim Koanhoi, Lee Hyun Sun, Kim Young Kook

机构信息

Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.

出版信息

Planta Med. 2002 Dec;68(12):1131-3. doi: 10.1055/s-2002-36358.

DOI:10.1055/s-2002-36358

PMID:12494344

Abstract

From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM ( 1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).

摘要

通过二酰基甘油酰基转移酶（DGAT）活性导向分级分离，从吴茱萸果实中分离出一种新的喹诺酮生物碱1-甲基-2-十四烷基-4（1H）-喹诺酮（1），以及三种已知的喹诺酮生物碱，吴茱萸次碱（2）、1-甲基-2-[(4Z,7Z)-4,7-癸二烯基]-4(1H)-喹诺酮（3）和1-甲基-2-[(6Z,9Z)-6,9-十五碳二烯基]-4(1H)-喹诺酮（4）。它们表现出剂量依赖性的DGAT抑制作用，IC50值分别为69.5微摩尔（1）、23.8微摩尔（2）、20.1微摩尔（3）和13.5微摩尔（4）。