吴茱萸变种飞龙掌血的生物碱成分及其对小鼠的急性毒性研究。
Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice.
作者信息
Yang X-W, Zhang H, Li M, Du L-J, Yang Z, Xiao S-Y
机构信息
State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, and Medical and Healthy Analysis Center, Peking University, Beijing, 100083, China.
出版信息
J Asian Nat Prod Res. 2006 Dec;8(8):697-703. doi: 10.1080/10286020412331286425.
Six alkaloids (1-6) have been isolated from the fruits of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang, two of which are new compounds, identified as 2-undecyl-4(1H)-quinolone (4) and 1-methyl-2-undecanone-10'-4(1H)-quinolone (5); the known compounds were identified as rutaecarpine (1), evodiamine (2), 1-methyl-2-undecyl-4(1H)-quinoline (3) and 2-undecanone-10'-4(1H)-quinolone (6). Compounds 1-5 were evaluated for their acute toxicity.
从吴茱萸（Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang）果实中分离出6种生物碱（1 - 6），其中2种为新化合物，分别鉴定为2 - 十一烷基 - 4(1H)-喹诺酮（4）和1 - 甲基 - 2 - 十一烷酮 - 10'-4(1H)-喹诺酮（5）；已知化合物鉴定为吴茱萸次碱（1）、吴茱萸碱（2）、1 - 甲基 - 2 - 十一烷基 - 4(1H)-喹啉（3）和2 - 十一烷酮 - 10'-4(1H)-喹诺酮（6）。对化合物1 - 5进行了急性毒性评价。
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