Sipos W, Schmoll F, Wimmers K
II. Medizinischen Universitätsklinik für Klauentiere der Veterinärmedizinischen Universität Wien.
Dtsch Tierarztl Wochenschr. 2002 Nov;109(11):470-80.
The introduction deals with immunogenetic investigations on the field of life-stock. The main chapter is outlined as a tabular overview of current opportunities of the application of indicator traits as well as marker and causal genes in breeding for disease resistance in cattle, sheep, goats and swine. In the discussion of the second part, emphasis was layed on diseases of small ruminants in central and western Europe. Indicator traits are discussed with respect of their advantages and disadvantages. The rigorous selection of specific traits is connected with an increase of the number of homozygotes. In contrary, pathogens do undergo mutations, thus escaping the host's immune system. Out of this point of view it is advisable, to set on selection very cautiously. The role of technologies of modern immunogenetics is pointed out in respect of constructing disease resistant animals.
引言部分涉及家畜领域的免疫遗传学研究。主要章节以表格形式概述了目前在牛、羊、山羊和猪的抗病育种中应用指示性状以及标记基因和因果基因的机会。在第二部分的讨论中，重点放在了中欧和西欧小型反刍动物的疾病上。讨论了指示性状的优缺点。严格选择特定性状会导致纯合子数量增加。相反，病原体确实会发生突变，从而逃避宿主的免疫系统。从这一观点来看，谨慎进行选择是明智的。指出了现代免疫遗传学技术在培育抗病动物方面的作用。
