Borrelli F, Izzo A A, Di Carlo G, Maffia P, Russo A, Maiello F M, Capasso F, Mascolo N
Department of Experimental Pharmacology, University of Naples 'Federico II', Via D. Montesano 49, 80131, Naples, Italy.
Fitoterapia. 2002 Nov;73 Suppl 1:S38-43. doi: 10.1016/s0367-326x(02)00189-2.
We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.
我们已经研究了蜂胶及其主要活性成分咖啡酸苯乙酯（CAPE）对大鼠结肠体内异常隐窝病灶（ACF）形成和肿瘤的影响。CAPE（腹腔注射50mg/kg）减少了由氧化偶氮甲烷诱导的ACF和肿瘤的形成，而蜂胶乙醇提取物则没有效果。这些结果表明CAPE具有潜在的抗癌作用，而蜂胶则没有。
