包膜RNA病毒出芽的机制。
Mechanisms of enveloped RNA virus budding.
作者信息
Pornillos Owen, Garrus Jennifer E, Sundquist Wesley I
机构信息
Dept of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA.
出版信息
Trends Cell Biol. 2002 Dec;12(12):569-79. doi: 10.1016/s0962-8924(02)02402-9.
Abstract
To spread infection, enveloped viruses must bud from infected host cells. Recent research indicates that HIV and other enveloped RNA viruses bud by appropriating the cellular machinery that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies. This new model of virus budding has many potential implications for cell biology and viral pathogenesis.
摘要
为了传播感染，包膜病毒必须从受感染的宿主细胞中出芽。最近的研究表明，HIV和其他包膜RNA病毒通过利用通常用于形成囊泡的细胞机制出芽，这些囊泡会出芽进入称为多囊泡体的晚期内体区室。这种病毒出芽的新模型对细胞生物学和病毒发病机制有许多潜在影响。
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