Borchard F, Kremer K, Loose D A
Thoraxchir Vask Chir. 1975 Apr;23(2):83-97. doi: 10.1055/s-0028-1096930.
Auto-alloplastic arterial prostheses with a dacron mesh of 1 or 2 layers according to Sparks were investigated by light and electron microscopy after variable times of incorporation and perfusion. At the end of the organization-period the characteristic structure of the wall is composed of three layers. The interior layer is adapted to the form of the mandril, which holds the place of the lumen, the medial layer is formed according to the inforcing dacron-mesh. With increasing duration of incorporation the granulation tissue shows somewhat less inflammatory cells and capillaries and more collagen fibres. There were some characteristic disturbances of healing only partly due to infection, which resulted in focal or total necrosis of the granulation tissue: Not all of these findings were of clinical importance. Already after a perfusion time of 10 months an atherosclerosis of variable degree was found. This atherosclerosis started from mural thrombi and showed in the electron microscope proliferations of modified smooth muscle cells. Advantages and disadvantages of the autoalloplastic arterial prostheses are discussed.
根据斯帕克斯的方法，对带有1层或2层涤纶网的自体同种异体动脉假体在植入和灌注不同时间后进行了光镜和电镜研究。在组织形成期结束时，血管壁的特征性结构由三层组成。内层适应于占据管腔位置的心轴形状，中层根据增强的涤纶网形成。随着植入时间的增加，肉芽组织中的炎性细胞和毛细血管有所减少，胶原纤维增多。愈合过程中存在一些特征性紊乱，部分是由感染引起的，这导致了肉芽组织的局部或全部坏死：并非所有这些发现都具有临床意义。在灌注10个月后就已发现不同程度的动脉粥样硬化。这种动脉粥样硬化始于壁血栓，在电子显微镜下可见到修饰的平滑肌细胞增殖。文中讨论了自体同种异体动脉假体的优缺点。
