Pennell M D, Davies M I, Rasper J, Motzok I
J Nutr. 1976 Feb;106(2):265-74. doi: 10.1093/jn/106.2.265.
Fourteen experiments were concluded on the effect of protein and carbohydrate sources in the assay diets on the relative biological values (RBV) of food grade sodium iron pyrophosphate (NaFePP) and ferric orthophosphate (FePO4) vs. ferrous sulfate (FeSO4) for rats and chicks, using the response in blood hemoglobin to graded levels of supplemental iron as the assay criterion. Two trials were made with volunteers to estimate the RBV of NaFePP and FePO4 for humans, based on the increase in plasma iron 2 hours after ingestion of 100 mg of iron of a test dose following an overnight fast. The RBV of iron from NaFePP and FePO4 for rats were consistently lower when the basal diet contained nonfat dried milk (9 to 16 and 28, respectively, vs. FeSO4=100) than when casein was used (25 to 28 and 49, respectively). The addition of 22% beta-lactose, replacing sucrose in a diet containing casein fed to rats, significantly reduced the RBV of iron from NaFePP from 25 to 15; the addition of 22% alpha-lactose or 40% glucose in place of sucrose had no effect on the RBV of this iron source. The RBV of iron from NaFePP and FePO4 for chicks were 4 to 6 and 4, respectively, with the source of dietary protein having no effect. Very low RBV of iron from NaFePP and FePO4 (4.3 and 5.9, respectively, vs. FeSO4=100) were also obtained with human subjects.
进行了14项实验，以血液血红蛋白对分级补充铁水平的反应为测定标准，研究了试验日粮中蛋白质和碳水化合物来源对食品级焦磷酸钠铁（NaFePP）、正磷酸铁（FePO4）与硫酸亚铁（FeSO4）相比，对大鼠和雏鸡的相对生物学效价（RBV）的影响。对志愿者进行了两项试验，根据禁食过夜后摄入100毫克试验剂量铁后2小时血浆铁的增加情况，估计NaFePP和FePO4对人类的RBV。当基础日粮含有脱脂奶粉时，NaFePP和FePO4中铁对大鼠的RBV始终低于使用酪蛋白时（分别为9至16和28，而FeSO4 = 100）（分别为25至28和49）。在给大鼠喂食的含酪蛋白日粮中添加22%的β-乳糖代替蔗糖，可使NaFePP中铁的RBV从25显著降低至15；添加22%的α-乳糖或40%的葡萄糖代替蔗糖对该铁源的RBV没有影响。NaFePP和FePO4中铁对雏鸡的RBV分别为4至6和4，日粮蛋白质来源没有影响。在人类受试者中，NaFePP和FePO4中铁的RBV也非常低（分别为4.3和5.9，而FeSO4 = 100）。
