Swain James H, Glosser Logan D
Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
School of Medicine, Emory University, 100 Woodruff Circle, Atlanta, GA 30322, USA.
Nutrients. 2024 Nov 25;16(23):4029. doi: 10.3390/nu16234029.
BACKGROUND/OBJECTIVES: Iron-fortified foods reduce the incidence of iron deficiency anemia. However, the nutritional efficacy of heme iron fortificants is unclear.
In this study, we determined the hemoglobin regeneration efficiency (HRE) of a porcine-derived heme iron powder (HIP), treating anemic rats (hemoglobin (Hb) 3-6 g/dL) with 14-day repletion diets fortified with four different concentrations (12, 24, 36, or 48 mg iron/kg diets) of HIP or a control diet ("no added iron"); = 9-12/group.
Our results demonstrate an inverse association between HRE and increasing dietary iron from the HIP. The HRE ratios of diets containing the HIP powder at 12, 24, 36, or 48 mg iron/kg were 0.508, 0.268, 0.273, and 0.223, respectively. Based on the mean final Hb values at 14 d, the HRE ratio of the 12 mg iron/kg diet was significantly higher ( ≤ 0.05) compared to the other HIP diet groups; however, only the HIP provided in the 36 and 48 mg iron/kg diets restored hemoglobin to high enough levels (mean Hb > 6 g/dL) to correct anemia.
Our findings show that HIP at each of the concentrations tested increased Hb; moreover, when present at higher concentrations in the diet, the HIP is capable of restoring hemoglobin to resolve iron deficiency anemia.
背景/目的：铁强化食品可降低缺铁性贫血的发病率。然而，血红素铁强化剂的营养功效尚不清楚。
在本研究中，我们测定了猪源血红素铁粉（HIP）的血红蛋白再生效率（HRE），用添加四种不同浓度（12、24、36或48mg铁/千克日粮）的HIP或对照日粮（“不添加铁”）的14天补充日粮处理贫血大鼠（血红蛋白（Hb）3 - 6g/dL）；每组n = 9 - 12只。
我们的结果表明HRE与日粮中HIP铁含量增加呈负相关。铁含量为12、24、36或48mg/千克的含HIP粉末日粮的HRE比率分别为0.508、0.268、0.273和0.223。基于14天时的平均最终Hb值，12mg铁/千克日粮的HRE比率显著高于其他HIP日粮组（P≤0.05）；然而，只有36和48mg铁/千克日粮中提供的HIP能将血红蛋白恢复到足够高的水平（平均Hb>6g/dL）以纠正贫血。
我们的研究结果表明，测试的每种浓度的HIP均能提高Hb；此外，当在日粮中以较高浓度存在时，HIP能够恢复血红蛋白以解决缺铁性贫血。
