Trochimowicz H J, Reinhardt C F, Mullin L S, Azar A, Karrh B W
J Occup Med. 1976 Jan;18(1):26-30.
We have previously shown that many halocarbons and hydrocarbons are capable of producing cardiac sensitization. Briefly, the test method involved exposure of healthy, unanesthetized, beagle dogs to various inspired levels of sensitizing agent, followed by an intravenous dose (8 mug/kg) of epinephrine. Along, this epinephrine dose produces only mild ECG alterations, but, at threshold levels of a sensitizing agent, may induce a serious cardiac arrhythmia and sometimes death. Using the same test protocol, dogs with experimentally-induced myocardial infarctions were used to determine whether this type of heart condition might significantly lower the threshold for cardiac sensitization. Test results on three halocarbons showed no greater potential for cardiac sensitization among dogs having recovered from myocardial infarction as compared to normal, healthy animals.
我们之前已经表明，许多卤代烃和烃类能够产生心脏致敏作用。简要来说，测试方法包括将健康、未麻醉的比格犬暴露于不同吸入水平的致敏剂中，随后静脉注射剂量为8微克/千克的肾上腺素。单独使用该剂量的肾上腺素只会引起轻微的心电图改变，但在致敏剂达到阈值水平时，可能会诱发严重的心律失常，有时甚至导致死亡。使用相同的测试方案，对实验性诱发心肌梗死的犬进行测试，以确定这种心脏状况是否会显著降低心脏致敏的阈值。对三种卤代烃的测试结果表明，与正常健康动物相比，从心肌梗死中恢复的犬产生心脏致敏的可能性并没有更高。
