Michel M C, Mehlburger L, Bressel H-U, Goepel M
Departments of Medicine and Urology, University of Essen, Essen, Germany.
Prostate Cancer Prostatic Dis. 1998 Dec;1(6):332-335. doi: 10.1038/sj.pcan.4500267.
We have compared the results of treatment with tamsulosin (0.4 mg once daily) in subgroups of patients with lower urinary tract symptoms suggestive of benign prostatic obstruction, based on two large-scale, open-label, observational studies. Improvements of IPSS or Q(max) were largely unaffected by patient age. Patients with severe symptoms benefited at least as much from treatment as those with mild or moderate symptoms, and the majority of patients with severe symptoms were shifted to the moderate or even mild symptoms group. We conclude that tamsulosin is effective in patients of all age groups, and should be considered as an alternative to surgery even in patients with severe symptoms.
基于两项大规模、开放标签的观察性研究，我们比较了坦索罗辛（每日一次，0.4毫克）治疗提示良性前列腺梗阻的下尿路症状患者亚组的结果。国际前列腺症状评分（IPSS）或最大尿流率（Qmax）的改善在很大程度上不受患者年龄的影响。严重症状患者从治疗中获益至少与轻、中度症状患者一样多，并且大多数严重症状患者被转移到中度甚至轻度症状组。我们得出结论，坦索罗辛对所有年龄组的患者均有效，即使是严重症状的患者也应考虑将其作为手术的替代方案。
