Department of Urology, University of Utah Health Sciences, University of Utah, Salt Lake City, Utah.
Department of Urology, Icahn School of Medicine, Mount Sinai Health System, New York, New York.
J Urol. 2021 Apr;205(4):1126-1132. doi: 10.1097/JU.0000000000001504. Epub 2020 Dec 1.
Benign prostatic hyperplasia is one of the most common conditions seen by a general urologist. Validated questionnaires provide insight into patient symptoms, however office based uroflow devices are limited by the variability of voiding behavior. Using a home uroflow device, we assessed individual voiding variability, temporal distribution of voiding parameters and the impact of age on voiding.
Between April 2019 and June 2020, 19,824 unique voiding profiles were captured using the Stream Dx Uroflowmeter and retrospectively analyzed. Age and number of voids were summarized by mean±standard deviation. We used mixed effects models to compare average values and intrapatient variability of voiding parameters to time of day and age. The coefficient of variation was used to assess intrapatient variability.
A total of 637 patients were identified with 625 meeting inclusion criteria, producing 19,824 voids. Mean age was 67 (±10.2) years old, and each patient provided on average 5 (±3.3) voids a day through 7 days. Average intrapatient voiding parameters showed notable variability, where the coefficient of variation for maximum flow was 27.6% (95% CI 26.6-28.6). Early morning voids were associated with higher volume and lower number of voids. As age progressed, voiding profiles worsened in a linear fashion. Afternoon and evening voids were associated with reduced intrapatient variability relative to early morning voids.
Assessment of 19,824 uroflows using an accurate and precise home uroflow device demonstrates that an individual's voiding parameters vary greatly from day to day, throughout the day, and worsen with age. Multiple measurements performed at home provides a more realistic assessment of true voiding behavior by capturing individual voiding variability and can help urologists make better decisions in patient care.
良性前列腺增生是普通泌尿科医生最常见的病症之一。经过验证的问卷可深入了解患者的症状,但基于诊室的尿流率设备会受到排尿行为变化的限制。通过使用家用尿流率仪,我们评估了个体的排尿变异性、排尿参数的时间分布以及年龄对排尿的影响。
在 2019 年 4 月至 2020 年 6 月期间,使用 Stream Dx 尿流率仪共采集了 19824 个独特的排尿记录,并对其进行了回顾性分析。用平均值±标准差总结年龄和排尿次数。我们使用混合效应模型比较了一天中不同时间和年龄对平均尿流率参数和个体内变异性的影响。变异系数用于评估个体内变异性。
共确定了 637 名患者,其中 625 名符合纳入标准,共产生 19824 次排尿。平均年龄为 67(±10.2)岁,每位患者每天平均排尿 5(±3.3)次,持续 7 天。平均个体内排尿参数显示出明显的变异性,最大流率的变异系数为 27.6%(95%CI 26.6-28.6)。清晨的排尿量较大,排尿次数较少。随着年龄的增长,排尿模式呈线性恶化。下午和晚上的排尿与清晨相比,个体内变异性降低。
使用精确的家用尿流率仪评估 19824 次尿流,表明个体的排尿参数每天、全天都有很大差异,且随年龄增长而恶化。在家中进行多次测量可以通过捕捉个体的排尿变异性更真实地评估真实的排尿行为,帮助泌尿科医生在患者护理方面做出更好的决策。