Suppr超能文献

急性给予选择性5-羟色胺再摄取抑制剂(SSRI)会影响健康志愿者对社交线索的处理。

Acute SSRI administration affects the processing of social cues in healthy volunteers.

作者信息

Harmer C J, Bhagwagar Z, Perrett D I, Völlm B A, Cowen P J, Goodwin G M

机构信息

University Department of Psychiatry, Warneord Hospital, Oxford, UK.

出版信息

Neuropsychopharmacology. 2003 Jan;28(1):148-52. doi: 10.1038/sj.npp.1300004.

Abstract

Enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression. This response forms the major evidence for the role of serotonin in affective and social behaviour in humans. The present study investigated the effects of acute administration of the selective serotonin reuptake inhibitor (SSR1), citalopram (10 mg, i.v.) upon a measure of emotional processing in healthy female volunteers. Subjects completed a facial expression recognition task following infusion of citalopram or saline (between-subjects design, double-blind). Facial expressions associated with five basic emotions--happiness, sadness, fearfulness, anger and disgust--were displayed. Each face had been 'morphed' between neutral (0%) and each emotional standard (100%) in 10% steps, leading to a range of emotional intensities. Mood and subjective experience were also monitored throughout the testing session. Volunteers receiving citalopram detected a higher number of facial expressions of fear and happiness, with reduced response times, relative to those given the placebo. By contrast, changes in the recognition of other basic emotions were not observed following citalopram. Notable differences in mood were also not apparent in these volunteers. These results suggest that acute administration of antidepressant drugs may affect neural processes involved in the processing of social information. This effect may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions.

摘要

5-羟色胺神经传递增强在目前用于治疗抑郁症的药物的抗抑郁反应中起着重要作用。这一反应构成了5-羟色胺在人类情感和社会行为中作用的主要证据。本研究调查了选择性5-羟色胺再摄取抑制剂(SSRI)西酞普兰(10毫克,静脉注射)急性给药对健康女性志愿者情绪加工测量指标的影响。受试者在输注西酞普兰或生理盐水后完成面部表情识别任务(组间设计,双盲)。展示了与五种基本情绪——快乐、悲伤、恐惧、愤怒和厌恶——相关的面部表情。每张脸在中性表情(0%)和每种情绪标准表情(100%)之间以10%的步长进行“变形”,从而产生一系列情绪强度。在整个测试过程中还监测了情绪和主观体验。与接受安慰剂的志愿者相比,接受西酞普兰的志愿者检测到更多的恐惧和快乐面部表情,且反应时间缩短。相比之下,西酞普兰给药后未观察到其他基本情绪识别的变化。这些志愿者的情绪也没有明显差异。这些结果表明,抗抑郁药物的急性给药可能会影响参与社会信息加工的神经过程。这种效应可能代表了SSRI对社会和情绪加工的早期急性效应,这与其治疗作用相关。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验