Jonassen R, Chelnokova O, Harmer C, Leknes S, Landrø N I
Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, PO Box 1097, Blindern, 0317, Oslo, Norway,
Psychopharmacology (Berl). 2015 Mar;232(5):953-8. doi: 10.1007/s00213-014-3729-5. Epub 2014 Sep 7.
Early neurocognitive changes in emotional processing are seen following SSRI administration, which may be involved in mechanisms of action. However, the perceptual processes underpinning these effects have not been specified.
In a double-blind, placebo-controlled eye-tracking study, we assessed the effect of single dose of citalopram (20 mg) in 25 healthy females. Face stimuli with direct and averted gaze were presented while visual scan patterns and pupil sizes were monitored. Subjective state was monitored using visual analogue scales.
There were no significant effects of citalopram on subjective state. However, the citalopram group displayed increased saccade numbers and shorter fixation duration during face viewing compared to the placebo group. Volunteers receiving citalopram also showed reduced monitoring of the eye region irrespective of the direct or averted eye position of the stimuli. The citalopram group also showed significantly larger pupil sizes than the control group.
These results suggest that the SSRI administration affects the perceptual processing of face stimuli. The current pattern of findings is consistent with anxiogenic-like mechanisms early on in SSRI treatment. Eye-tracking provides a novel method to characterise and detect these effects.
服用选择性5-羟色胺再摄取抑制剂（SSRI）后可观察到情绪加工方面早期的神经认知变化，这可能涉及到其作用机制。然而，这些效应背后的感知过程尚未明确。
在一项双盲、安慰剂对照的眼动追踪研究中，我们评估了单剂量西酞普兰（20毫克）对25名健康女性的影响。呈现直视和回避注视的面部刺激时，监测视觉扫描模式和瞳孔大小。使用视觉模拟量表监测主观状态。
西酞普兰对主观状态无显著影响。然而，与安慰剂组相比，西酞普兰组在观看面部时扫视次数增加且注视持续时间缩短。接受西酞普兰的志愿者无论刺激的眼睛是直视还是回避位置，对眼睛区域的关注也减少。西酞普兰组的瞳孔大小也显著大于对照组。
这些结果表明，服用SSRI会影响面部刺激的感知加工。目前的研究结果模式与SSRI治疗早期的类焦虑机制一致。眼动追踪提供了一种表征和检测这些效应的新方法。
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