Sklivanioti Greenfield Myrto, Wang Yanlu, Martinsson Lina, Li Tie-Qiang, Msghina Mussie
Department of Clinical Neuroscience (CNS), Karolinska Institute, Stockholm, Sweden.
Department of Nuclear Medicine Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Psychopharmacology (Berl). 2025 Jun 19. doi: 10.1007/s00213-025-06835-6.
Cognitive control is crucial for optimal daily functioning and for emotional well-being. Cognitive control has been shown to be modified by experimental manipulations under widely differing experimental conditions, including cognitive training, and pharmacological intervention mainly probing catecholaminergic systems with little focus on the serotonergic system.
To explore the role of serotonin on cognitive control in emotional and non-emotional settings.
Behavioral, electrodermal and prefrontal activity measures were evaluated to compare the effects of single-session task repetition and single-dose serotonergic intervention with escitalopram on cognitive control in healthy participants, using cognitive and emotional Stroop tasks.
For cognitive Stroop, task repetition improved performance both 'on-line' within an ongoing task and 'off-line' after a four-hour delay, and escitalopram had no additional effects on this. In emotional Stroop, escitalopram enhanced the practice-related performance gain, starting from the second stimulus of each block. Compared to placebo, escitalopram also significantly reduced overall rate of premature responses. Regarding brain activation, escitalopram significantly reduced prefrontal activity during cognitive and even more so during emotional Stroop task. Lastly, electrodermal response showed significant habituation during cognitive but not emotional Stroop, in an effect that was not significantly modified by escitalopram.
Cognitive control in emotional and non-emotional settings may respond differently to behavioral and pharmacological manipulations. Escitalopram may selectively improve cognitive control in an emotional setting compared to cognitive control in non-emotional settings.
认知控制对于最佳日常功能和情绪健康至关重要。研究表明，在广泛不同的实验条件下，包括认知训练和主要探究儿茶酚胺能系统而很少关注血清素能系统的药物干预，认知控制会受到实验操作的影响。
探讨血清素在情绪和非情绪环境中对认知控制的作用。
使用认知和情绪Stroop任务，评估行为、皮肤电活动和前额叶活动测量指标，以比较单次任务重复和单剂量艾司西酞普兰血清素能干预对健康参与者认知控制的影响。
对于认知Stroop任务，任务重复在正在进行的任务中“在线”提高了表现，并且在延迟四小时后“离线”也有提高，而艾司西酞普兰对此没有额外影响。在情绪Stroop任务中，从每个组块的第二个刺激开始，艾司西酞普兰增强了与练习相关的表现提升。与安慰剂相比，艾司西酞普兰还显著降低了过早反应的总体发生率。关于大脑激活，艾司西酞普兰在认知Stroop任务期间显著降低了前额叶活动，在情绪Stroop任务期间更是如此。最后，皮肤电反应在认知Stroop任务期间显示出显著的习惯化，但在情绪Stroop任务中没有，且这种效应未被艾司西酞普兰显著改变。
情绪和非情绪环境中的认知控制可能对行为和药物操作有不同反应。与非情绪环境中的认知控制相比，艾司西酞普兰可能在情绪环境中选择性地改善认知控制。
