Hall C W, Adams L M, Ghidoni J J
Trans Am Soc Artif Intern Organs. 1975;21:281-8.
The skin interfacing potential of various velours, felts, foams and rough cast surfaces of some polymers was investigated by bonding these substances to solid core silastic rods using Dow-Corning Medical Adhesive Type A. These dummy cannulae were implanted as skin penetrating rods onto the dorsum of canines, goats, and swine. Vitreous carbon buttons were also investigated as to their potential. Over 200 individual implants were made and some retained in place for 2 yrs. Only the nylon and dacron velours held much promise as a long-term interfacing material. A "growth phenomenon" was observed using the velour material and this, we feel, is related to a permanent marriage between basal cells and adjacent monofilament fibers. Subsequent maturation of these cells carries the monofilament fibers to the surface causing the entire cannula to "grow". Since the maturation rate is apparently slower in humans, it does not detract from their potential application. The maturation rate is also much more rapid on the dorsum than on the ventral surfaces.
通过使用道康宁A型医用粘合剂将各种天鹅绒、毛毡、泡沫以及某些聚合物的粗糙铸造表面与实心硅胶棒粘合，研究了它们与皮肤的接触潜力。这些模拟插管作为皮肤穿刺棒植入犬、山羊和猪的背部。还研究了玻璃碳纽扣的潜力。进行了200多次个体植入，一些植入物在体内保留了两年。只有尼龙和涤纶天鹅绒有望成为长期接触材料。使用天鹅绒材料时观察到一种“生长现象”，我们认为这与基底细胞和相邻单丝纤维之间的永久结合有关。这些细胞随后的成熟将单丝纤维带到表面，导致整个插管“生长”。由于人类的成熟速度明显较慢，这并不影响它们的潜在应用。背部的成熟速度也比腹部表面快得多。
