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[Hepatoprotective effects of gamma-L-glutamylhistamine].

作者信息

Zheltukhina G A, Nebol'sin V E, Krzhechkovskaia V V, Evstigneeva R P

机构信息

M. V. Lomonosov Moscow State Academy of Fine Chemical Technology, 117571, Moscow, Vernadskogo pr. 86.

出版信息

Vopr Med Khim. 2002 Sep-Oct;48(5):443-9.

Abstract

The influence of gamma-GluHA and glutarylhistamine on the lipid peroxidation, cholesterol, phospholipid and liver aminotransferase activity was investigated using carbon tetrachloride-induced model of subacute liver damage. Pretreatment of rats with gamma-GluHA and glutarylhistamine prevented liver necrosis and normalized activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood plasma, lipid peroxidation in the liver and plasma, lipid profiles and cholesterol content in the liver and plasma.

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