2-去甲氧基羰基-2-乙氧基羰基-11-脱氧米索前列醇的肝保护作用

[Hepatoprotective effect of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol].

作者信息

Sapozhnikova T A, Zarudiĭ F S, Baschenko N Zh, Makara N S, Khisamutdinova R Iu, Gabdrakhmanova S F, Ivanova N A, Nazarov V S

出版信息

Eksp Klin Farmakol. 2007 Jul-Aug;70(4):30-1.

PMID:18078039

Abstract

2-Demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol (11-DMP) produces antioxidant effect on the models of toxic hepatitis induced by paracetamol and carbon tetrachloride. The drug normalizes the lipid peroxidation (LPO) prosess in rat liver of the rat and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the rat blood, thus demonstrating hepatoprotective action.

摘要

2-脱甲氧基羰基-2-乙氧基羰基-11-脱氧米索前列醇（11-DMP）对扑热息痛和四氯化碳诱导的中毒性肝炎模型产生抗氧化作用。该药物使大鼠肝脏中的脂质过氧化（LPO）过程以及大鼠血液中天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的水平恢复正常，从而显示出肝保护作用。