甲基汞毒性相关细胞内因子的研究。
Investigation of intracellular factors involved in methylmercury toxicity.
作者信息
Naganuma Akira, Furuchi Takemitsu, Miura Nobuhiko, Hwang Gi-Wook, Kuge Shusuke
机构信息
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
出版信息
Tohoku J Exp Med. 2002 Feb;196(2):65-70. doi: 10.1620/tjem.196.65.
Methylmercury is a known pollutant that causes severe central nervous system disorders. It is capable of passing through the blood-brain barrier and accumulates in cerebral cells. However, little is known regarding the mechanism of its toxicity at the molecular level. Using yeast cells, we searched for the genes involved in the expression of methylmercury toxicity, and found that genes encoding L-glutamine.D-fructose-6-phosphate amidotransferase (GFAT) and ubiquitin transferase (Ubc3) confer methylmercury resistance on the cells. It has also been shown that GFAT is the target molecule of methylmercury in yeast cells. These findings provide important clues about the mechanism underlying methylmercury toxicity in mammals.
甲基汞是一种已知的污染物，可导致严重的中枢神经系统紊乱。它能够穿过血脑屏障并在脑细胞中蓄积。然而，关于其在分子水平上的毒性机制却知之甚少。我们利用酵母细胞寻找与甲基汞毒性表达相关的基因，发现编码L-谷氨酰胺-D-果糖-6-磷酸酰胺转移酶（GFAT）和泛素转移酶（Ubc3）的基因赋予细胞对甲基汞的抗性。研究还表明，GFAT是酵母细胞中甲基汞的靶分子。这些发现为哺乳动物体内甲基汞毒性的潜在机制提供了重要线索。
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