Strocchi Rita, Orsini Giovanna, Iezzi Giovanna, Scarano Antonio, Rubini Corrado, Pecora Gabriele, Piattelli Adriano
Dental School of the University of Chieti, Italy.
J Oral Implantol. 2002;28(6):273-8. doi: 10.1563/1548-1336(2002)028<0273:BRWCSE>2.3.CO;2.
Autologous bone is the preferred bone graft material because it carries proteins as bone-enhancing substrates, minerals, and vital bone cells. Calcium sulfate (CS) is a well-tolerated, biodegradable, osteoconductive bone graft substitute and is a reasonable alternative to autogenous bone graft. Blood vessels are an important component of bone formation and maintenance. The process of vascular induction is called angiogenesis, and it plays a key role in all regenerative processes. Bone tissue differentiation is related to the local presence of blood vessels. One method to evaluate the presence of blood vessels in a tissue is to count the microvessels to evaluate microvessel density (MVD). The aim of the present study was to conduct a comparative evaluation of microvessel density in sites treated with CS and autologous bone in rabbits, with or without e-PTFE nonresorbable membranes (Gore-Tex, Flagstaff, Ariz). Nine New Zealand rabbits, each weighing about 2.5 kg, were used in this experiment. Three 6-mm wide defects were created in each tibial metaphysis. The defects were filled in a random way. The defects of group 1 (3 rabbits) were filled with CS granules (Surgiplaster, Classimplant, Rome, Italy) and covered with e-PTFE membranes. The defects in group 2 (3 rabbits) were filled with CS granules (Surgiplaster). The defects in group 3 (3 rabbits) were filled with autologous bone. A total of 54 defects were filled (18 with CS and e-PTFE membranes, 18 with CS alone, and 18 with autologous bone). No postoperative deaths or complications occurred. All nine animals were sacrificed at 4 weeks. MVD results were as follows: in the first group, 9.88 +/- 4.613; in the second group, 7.92 +/- 1.998; and in the third group, 5.56 +/- 1.895. P = .000 was highly significant. Statistically significant differences were found between groups 1 and 3, 1 and 2, and 2 and 3. The presence of more blood vessels in the sites treated with CS could help to explain the good results reported in the literature with the use of CS.
自体骨是首选的骨移植材料，因为它携带着作为骨增强基质的蛋白质、矿物质和重要的骨细胞。硫酸钙（CS）是一种耐受性良好、可生物降解的骨传导性骨移植替代物，是自体骨移植的合理替代品。血管是骨形成和维持的重要组成部分。血管诱导过程称为血管生成，它在所有再生过程中起关键作用。骨组织分化与局部血管的存在有关。评估组织中血管存在情况的一种方法是计数微血管以评估微血管密度（MVD）。本研究的目的是对兔中使用CS和自体骨治疗的部位的微血管密度进行比较评估，有无e-PTFE不可吸收膜（Gore-Tex，弗拉格斯塔夫，亚利桑那州）。本实验使用了9只体重约2.5千克的新西兰兔。在每个胫骨干骺端制造三个6毫米宽的缺损。缺损以随机方式填充。第1组（3只兔）的缺损用CS颗粒（Surgiplaster，Classimplant，罗马，意大利）填充并用e-PTFE膜覆盖。第2组（3只兔）的缺损用CS颗粒（Surgiplaster）填充。第3组（3只兔）的缺损用自体骨填充。总共填充了54个缺损（18个用CS和e-PTFE膜，18个仅用CS，18个用自体骨）。术后无死亡或并发症发生。所有9只动物在4周时处死。MVD结果如下：第一组为9.88±4.613；第二组为7.92±1.998；第三组为5.56±1.895。P = 0.000具有高度显著性。在第1组和第3组、第1组和第2组以及第2组和第3组之间发现了统计学上的显著差异。CS治疗部位血管较多可能有助于解释文献中报道的使用CS的良好结果。
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