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用生物活性玻璃颗粒、硫酸钙屏障或两种材料的组合治疗手术造成的缺损中的骨愈合。大鼠胫骨的组织学和组织计量学研究。

Bone healing in surgically created defects treated with either bioactive glass particles, a calcium sulfate barrier, or a combination of both materials. A histological and histometric study in rat tibias.

作者信息

Melo Luiz G N, Nagata Maria J H, Bosco Alvaro F, Ribeiro Luciana L G, Leite Cristiane M

机构信息

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, University of State of São Paulo Júlio de Mesquita Filho-UNESP, Araçatuba, Brazil.

出版信息

Clin Oral Implants Res. 2005 Dec;16(6):683-91. doi: 10.1111/j.1600-0501.2005.01090.x.

Abstract

OBJECTIVE

The purpose of this study was to histologically analyze the influence of bioactive glass and/or a calcium sulfate barrier on bone healing in surgically created defects in rat tibias.

MATERIAL AND METHODS

Sixty-four rats were divided into 4 groups: C (control), CS (calcium sulfate), BG (bioactive glass), and BG/CS (bioactive glass/calcium sulfate). A surgical defect was created in the tibia of each animal. In Group CS, a calcium sulfate barrier was placed to cover the defect. In Group BG the defect was filled with bioactive glass. In Group BG/CS, it was filled with bioactive glass and protected by a barrier of calcium sulfate. Animals were sacrificed at 10 or 30 days post-operative. The formation of new bone in the cortical area of the defect was evaluated histomorphometrically.

RESULTS

At 10 days post-operative, Group C presented significantly more bone formation than Groups CS, BG, or BG/CS. No statistically significant differences were found between the experimental groups. At 30 days post-operative, Group C demonstrated significantly more bone formation than the experimental groups. Groups CS and BG/CS showed significantly more bone formation than Group BG. No statistically significant differences were found between Group CS and BG/CS.

CONCLUSIONS

(a) the control groups had significantly more bone formation than the experimental groups; (b) at 10 days post-operative, no significant differences were found between any of the experimental groups; and (c) at 30 days post-operative, the groups with a calcium sulfate barrier had significantly more bone formation than the group that used bioactive glass only.

摘要

目的

本研究旨在通过组织学分析生物活性玻璃和/或硫酸钙屏障对大鼠胫骨手术造成的缺损处骨愈合的影响。

材料与方法

64只大鼠分为4组:C组(对照组)、CS组(硫酸钙组)、BG组(生物活性玻璃组)和BG/CS组(生物活性玻璃/硫酸钙组)。对每只动物的胫骨制造一个手术缺损。在CS组中,放置硫酸钙屏障覆盖缺损处。在BG组中,缺损处填充生物活性玻璃。在BG/CS组中,缺损处填充生物活性玻璃并用硫酸钙屏障保护。术后10天或30天处死动物。对缺损处皮质区域新骨形成进行组织形态计量学评估。

结果

术后10天,C组的骨形成明显多于CS组、BG组或BG/CS组。各实验组之间未发现统计学上的显著差异。术后30天,C组的骨形成明显多于各实验组。CS组和BG/CS组的骨形成明显多于BG组。CS组和BG/CS组之间未发现统计学上的显著差异。

结论

(a)对照组的骨形成明显多于实验组;(b)术后10天,各实验组之间未发现显著差异;(c)术后30天,有硫酸钙屏障的组的骨形成明显多于仅使用生物活性玻璃的组。

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