Heijer Tom den, Skoog Ingmar, Oudkerk Matthijs, de Leeuw Frank-Erik, de Groot Jan Cees, Hofman Albert, Breteler Monique M B
Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 sDR, Rotterdam, The Netherlands.
Neurobiol Aging. 2003 Mar-Apr;24(2):307-13. doi: 10.1016/s0197-4580(02)00088-x.
The relation between blood pressure level and degree of global brain atrophy is equivocal. We evaluated past and present blood pressure levels and change in blood pressure over 20 years in relation to the degree of cortical atrophy on magnetic resonance imaging (MRI). In 1995-1996, we measured blood pressure and performed MRI in 1077 nondemented elderly (age 60-90 years). For 513 of these, we had information on a blood pressure level 20 years before. The degree of cortical atrophy was semi-quantitatively scored (range 0-15). In late life, a high (>/=90 mmHg) and low (<65 mmHg) diastolic blood pressure were associated with more cortical atrophy than a diastolic blood pressure level between 65-74 mmHg (adjusted difference 0.60 units (95% confidence interval (CI), 0.18-1.02) and 0.77 units (0.28-1.25), respectively). Persons whose diastolic blood pressure had declined more than 10 mmHg over 20 years had more cortical atrophy than those with stable blood pressure levels (adjusted difference 0.53 units, 0.05-1.02). Both high and declining diastolic blood pressure levels are associated with more global brain atrophy on MRI.
血压水平与全脑萎缩程度之间的关系并不明确。我们评估了过去和当前的血压水平以及20年间血压的变化与磁共振成像（MRI）上皮质萎缩程度的关系。在1995 - 1996年，我们对1077名非痴呆老年人（年龄60 - 90岁）测量了血压并进行了MRI检查。其中513人，我们有其20年前血压水平的信息。皮质萎缩程度进行了半定量评分（范围0 - 15）。在晚年，舒张压高（≥90 mmHg）和低（<65 mmHg）与皮质萎缩程度高于舒张压在65 - 74 mmHg之间者相关（校正差异分别为0.60单位（95%置信区间（CI），0.18 - 1.02）和0.77单位（0.28 - 1.25））。20年间舒张压下降超过10 mmHg的人比血压水平稳定者有更多的皮质萎缩（校正差异0.53单位，0.05 - 1.02）。舒张压高和下降都与MRI上更严重的全脑萎缩相关。
