来自一株对青霉素-头孢菌素耐药的肺炎球菌分离株的PBP 1A的位点特异性诱变分析。
Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate.
作者信息
Smith Anthony M, Klugman Keith P
机构信息
Respiratory and Meningeal Pathogens Research Unit, Department of Clinical Microbiology and Infectious Diseases, National Health Laboratory Service, Johannesburg, South Africa.
出版信息
Antimicrob Agents Chemother. 2003 Jan;47(1):387-9. doi: 10.1128/AAC.47.1.387-389.2003.
Abstract
Our mutagenesis study has investigated all amino acid mutations in the penicillin-binding domain of PBP 1A from Hungarian pneumococcal isolate 3191 to determine the importance of every mutation in the development of penicillin and cefotaxime resistance. Our data reveal that mutations at amino acid positions 574 to 577 and position 539 cause penicillin and cefotaxime resistance.
摘要
我们的诱变研究调查了来自匈牙利肺炎球菌分离株3191的PBP 1A青霉素结合结构域中的所有氨基酸突变，以确定每种突变在青霉素和头孢噻肟耐药性发展中的重要性。我们的数据表明，氨基酸位置574至577以及位置539处的突变会导致对青霉素和头孢噻肟产生耐药性。
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