Murray Peter E, Windsor L Jack, Smyth Thomas W, Hafez Abeer A, Cox Charles F
Department of Oral Biology, Indiana University School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA.
Crit Rev Oral Biol Med. 2002;13(6):509-20. doi: 10.1177/154411130201300607.
Every year, despite the effectiveness of preventive dentistry and dental health care, 290 million fillings are placed each year in the United States; two-thirds of these involve the replacement of failed restorations. Improvements in the success of restorative treatments may be possible if caries management strategies, selection of restorative materials, and their proper use to avoid post-operative complications were investigated from a biological perspective. Consequently, this review will examine pulp injury and healing reactions to different restorative variables. The application of tissue engineering approaches to restorative dentistry will require the transplantation, replacement, or regeneration of cells, and/or stimulation of mineralized tissue formation. This might solve major dental problems, by remineralizing caries lesions, vaccinating against caries and oral diseases, and restoring injured or replacing lost teeth. However, until these therapies can be introduced clinically, the avoidance of post-operative complications with conventional therapies requires attention to numerous aspects of treatment highlighted in this review.
尽管预防牙科和口腔保健措施行之有效，但美国每年仍有2.9亿颗牙齿需要补牙；其中三分之二是用于替换失败的修复体。如果能从生物学角度研究龋病管理策略、修复材料的选择及其正确使用以避免术后并发症，那么修复治疗的成功率或许能够得到提高。因此，本综述将探讨牙髓损伤以及对不同修复变量的愈合反应。将组织工程方法应用于修复牙科需要进行细胞移植、替换或再生，和/或刺激矿化组织形成。这或许可以通过使龋损再矿化、接种预防龋齿和口腔疾病的疫苗以及修复受损牙齿或替换缺失牙齿来解决主要的牙科问题。然而，在这些疗法能够临床应用之前，采用传统疗法避免术后并发症需要关注本综述中强调的治疗的诸多方面。
