原发性震颤患者血液中β-咔啉生物碱水平升高。
Elevation of blood beta-carboline alkaloids in essential tremor.
作者信息
Louis E D, Zheng W, Jurewicz E C, Watner D, Chen J, Factor-Litvak P, Parides M
机构信息
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
出版信息
Neurology. 2002 Dec 24;59(12):1940-4. doi: 10.1212/01.wnl.0000038385.60538.19.
BACKGROUND
beta-Carboline alkaloids are normal body constituents but are also potent tremor-producing chemicals that are naturally present in the food chain.
OBJECTIVE
To explore the hypothesis that high concentrations of beta-carboline alkaloids are associated with essential tremor (ET).
METHODS
One hundred cases and 100 controls were frequency matched on age, sex, and ethnicity. Blood concentrations of harmane and harmine were quantified by high-performance liquid chromatography, blinded to clinical information.
RESULTS
The mean log blood concentration of harmane was higher in cases than controls (0.72 +/- 0.53 vs 0.51 +/- 0.64 g(-10)/mL; p = 0.01). A nonparametric test on nontransformed data (median harmane = 5.21 g(-10)/mL in cases and 2.28 g(-10)/mL in controls) confirmed this difference (p = 0.005). The mean log blood concentration of harmine was 0.20 +/- 0.48 g(-10)/mL in cases and 0.10 +/- 0.65 g (-10)/mL in controls (p = 0.20). Log harmane concentrations were stratified based on the median value; 62% of cases vs 39% of controls had a high log harmane concentration (p = 0.001). Mean log harmane concentration was similar in the cases with (0.74 +/- 0.58 g(-10)/mL) and without (0.71 +/- 0.50 g(-10)/mL) an affected relative (p = 0.83).
CONCLUSIONS
Blood concentrations of harmane were measured in ET cases compared with controls. Concentrations were elevated in cases with and without a family history of ET.
背景
β-咔啉生物碱是人体正常成分，但也是食物链中天然存在的强效致颤化学物质。
目的
探讨高浓度β-咔啉生物碱与特发性震颤（ET）相关的假说。
方法
100例患者和100名对照在年龄、性别和种族上进行频率匹配。通过高效液相色谱法对去氢骆驼蓬碱和骆驼蓬碱的血药浓度进行定量分析，分析过程对临床信息保密。
结果
患者组去氢骆驼蓬碱的平均对数血药浓度高于对照组（0.72±0.53对0.51±0.64 g⁻¹⁰/mL；p = 0.01）。对未转换数据进行的非参数检验（患者组去氢骆驼蓬碱中位数 = 5.21 g⁻¹⁰/mL，对照组为2.28 g⁻¹⁰/mL）证实了这一差异（p = 0.005）。患者组骆驼蓬碱的平均对数血药浓度为0.20±0.48 g⁻¹⁰/mL，对照组为0.10±0.65 g⁻¹⁰/mL（p = 0.20）。根据中位数对去氢骆驼蓬碱浓度的对数进行分层；62%的患者组和39%的对照组去氢骆驼蓬碱浓度对数较高（p = 0.001）。有患病亲属的患者组（0.74±0.58 g⁻¹⁰/mL）和无患病亲属的患者组（0.71±0.50 g⁻¹⁰/mL）的去氢骆驼蓬碱平均对数浓度相似（p = 0.83）。
结论
对ET患者和对照组的去氢骆驼蓬碱血药浓度进行了测量。有或无ET家族史的患者组浓度均升高。
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