Terashita Keijiro, Nishimura Takehiko, Natsuyama Susumu
Department of Engineering, Osaka Prefecture University, Sakai, Osaka, Japan.
Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1550-7. doi: 10.1248/cpb.50.1550.
For the purpose of evaluating optimal fill level of starting materials in a high-shear mixer, discrete element method (DEM) simulation was conducted to visualize kinetic status between particles. The simulation results obtained by changing fill levels were used to determine solid fraction of particles, particle velocity, particle velocity vector, and kinetic energy and discuss the flow pattern. Optimal fill level was obtained from the information on these matters. It was pointed out that understanding the kinetic energy between particles in an agitating vessel was effective in determining the optimal fill level. Granulation experiment was conducted to validate the optimal fill level obtained by the simulation, confirming the good agreement between these two results. It was pointed out that determination of kinetic energy between particles through the simulation was effective in obtaining an index of the kinetic status of particles. Further, it was confirmed that the simulation could provide more information than conventional granulation experiments could provide and also helpful in optimizing the operating conditions.
为了评估高剪切混合器中起始物料的最佳填充水平，采用离散单元法（DEM）模拟来可视化颗粒间的动力学状态。通过改变填充水平获得的模拟结果用于确定颗粒的固相分数、颗粒速度、颗粒速度矢量和动能，并讨论流动模式。从这些方面的信息中获得了最佳填充水平。结果表明，了解搅拌容器中颗粒间的动能对于确定最佳填充水平是有效的。进行了制粒实验以验证模拟得到的最佳填充水平，证实了这两个结果之间的良好一致性。结果表明，通过模拟确定颗粒间的动能对于获得颗粒动力学状态指标是有效的。此外，还证实了该模拟能够提供比传统制粒实验更多的信息，并且有助于优化操作条件。
