包衣锅中片剂运动的计算机模拟
Computer simulation of tablet motion in coating drum.
作者信息
Yamane K, Sato T, Tanaka T, Tsuji Y
机构信息
Department of Quality Control, Taiho Pharmaceutical Co., Ltd, Tokushima, Japan.
出版信息
Pharm Res. 1995 Sep;12(9):1264-8. doi: 10.1023/a:1016201102355.
PURPOSE
The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation.
METHODS
DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation.
RESULTS
The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers.
CONCLUSIONS
It is found that DEM is a useful method of predicting tablet motion in a coating drum.
目的
目的是开发一种利用计算机模拟在片剂包衣操作中寻找最佳条件的新方法。
方法
本模拟使用离散单元法（DEM），通过对牛顿运动方程进行数值积分来计算单个片剂的轨迹。
结果
片剂尺寸、片剂装载量、转速对平均表面时间、循环时间和表面时间偏差的影响与其他研究人员的实验结果在定性上一致。
结论
发现离散单元法是预测包衣滚筒中片剂运动的一种有用方法。
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