Itaya Taisuke, Kanai Tae
Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.
Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1584-8. doi: 10.1248/cpb.50.1584.
1-Benzylwye (8) underwent electrophilic substitution at the 7-position in the presence of phosgene and pyridine in tetrahydrofuran (THF) to afford the 1,4-dihydropyridines (11, 10, and 14) together with the carboxylic acid 6 and its methyl ester 2 after short treatment of the reaction mixture with methanol and then with water. When triethylamine was used instead of pyridine, phosgene reacted with triethylamine rather than 8, producing (E)-3-(diethylamino)propenoyl chloride (17) and diethylcarbamoyl chloride (18).
1-苄基怀（8）在光气和吡啶存在下于四氢呋喃（THF）中在7位发生亲电取代反应，在将反应混合物先用甲醇短时间处理然后用水处理后，得到1,4-二氢吡啶（11、10和14）以及羧酸6及其甲酯2。当用三乙胺代替吡啶时，光气与三乙胺而不是8反应，生成（E）-3-（二乙氨基）丙烯酰氯（17）和二乙氨基甲酰氯（18）。
